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    • 专利摘要:
    The present invention describes a refractive multifocal intraocular lens with aspherical geometry on its two surfaces such that the local optical power card of the lens, associated with the cornea, has a central zone of intermediate optical power surrounded by an optical power ring maximum with a gradual transition between the two regions, followed by an alternation of rings of varying power with areas of gradual transition between the rings.
    公开号:BE1022036B1
    申请号:E2013/0875
    申请日:2013-12-27
    公开日:2016-02-08
    发明作者:Gutierrez David Fernandez；Diaz Carlos Dorronsoro；Briones Sergio Barbero；Celestino Susana Marcos
    申请人:Consejo Superior De Investigaciones Cientificas (Csic)；
    IPC主号:
    专利说明:

    OPTICALLY OPTICALLY OPTICALLY OPTICALLY OPTICALLY OPTIMIZED MULTIFOCAL REFRACTIVE LAMINATE LENS AND METHOD FOR PREPARING THE SAME
    PRODUCTION
    Field of the invention
    The present invention is generally apparent in the field of ophthalmology and in particular the design of ophthalmic lenses.
    Description of the Prior Art The human eye consists of two lenses, namely the cornea and the lens, which project images of the outside world onto the retina. In the young eye, the crystalline lens is able to modify its shape and focus distant and close objects, a mechanism referred to as the "accommodation". This ability of accommodation is gradually lost with age. In addition, aging is accompanied by a loss of transparency of the lens, a process that results in the formation of a cataract. Cataract surgery involves replacing the natural lens of the eye with an intraocular lens.
    Multifocal intraocular lenses restore transparency to the eye. In addition, by knowing the ocular biometry of the patient, it is possible to select the power of the intraocular lens so as to correct the refractive error of the patient.
    The main parameters used to describe the design of the optics of an intraocular lens are the diameter of the optical zone, the shape of its surfaces, the material of which it is composed and the central thickness. The thickness of the edge of the lens is a derived quantity, which results from the central thickness and the shape of the surfaces but which plays an important role because it represents the junction zone with the haptics, the latter conferring on the lens to The present invention relates solely to the optical design of an intraocular lens, which can therefore be associated with various mechanical configurations outside the optical zone, especially at the level of haptics.
    In recent times, optical designs of monofocal intraocular lenses to correct spherical aberration of the cornea or, in general, seeking to optimize the optical quality of distant vision at the level of the fovea, or even in the peripheral areas of the field of view, have been optimized. With the implantation of a monofocal intraocular lens as a replacement for the natural lens, the eye loses its residual accommodation capacity in the presence of the same lens. If the power of the lens is well adjusted for long distances, as is customary, these lenses do not allow the patient to see clearly close, and require an additional correction (usually refractive glasses positive) for the performing certain tasks closely.
    In the past, multifocal lenses have been developed, which resulted from principles of refractive optics and diffractive optics, in an attempt to overcome this problem. The proposed refractive multifocal lenses usually consist of an optical zone divided into different sections. They normally have a central circular section and one or more peripheral annular regions, with different radii of curvature for each of them, so that different powers are obtained in the different regions of the optical zone. For example, lenses with a high-power central circular region for near vision, surrounded by a single ring of lower power for far vision (US3420006), lenses with concentric regions with alternating rings, have been reported. for near and far vision (US5158572, US6835204, US568223). Lenses using concentric sections with progressive transitions between these concentric regions, aspheric, or aspherical and spherical zones (US5112351, US5326348, US5715031) have also been reported. It has recently been reported non-concentric segments presenting one region for far vision and another for near vision (US20120029631, US7287852). It has also been reported lenses with aspherical profiles, with a refractive profile continuously variable, to increase the depth of focus (US4580882).
    Multizone (US7381221) and aspherical (Tecnis or Acrysof) profiles are also used to focus the light at a single focal point by combining the optics of the cornea and the intraocular lens and correcting the high order aberrations of the lens. 'eye. For this purpose, aspheric designs of coefficients up to order 10 have been proposed (US4504982).
    In addition to refractive multifocal lenses, another solution is represented by diffractive lenses. These lenses operate via the principles of diffractive optics and focus the light in two focal points, one far and one close (US20090088840). It has also been proposed trifocal designs (US20110292335, EP20110181646, US20120224138, US8235525), with an intermediate focal point.
    Multi-zone refractive lenses may exhibit diffraction problems (halos due to abrupt power changes between zones), have limitations in their performance due to the fact that the pupil size of the patient is variable, and, in general, are limited at two or three focal points, causing blurred images in the intermediate focal positions. The aspherical designs proposed, if they allow some extension of the focusing depth, offer only poor optical quality control over the various focusing points.
    One of the disadvantages of diffractive lenses is that the image quality in the intermediate focal areas, out of the peaks corresponding to the nominal focal points, is very low because the images are out of focus. Another disadvantage of these diffractive lenses is that they are optimized for a given wavelength, and in polychromatic light they have chromatic effects of halos. However, diffractive lenses have multifocal properties (simultaneous vision) for any diameter of the pupil of the eye, their multifocal performance is not limited by the light conditions and the effect of pupillary miosis.
    Description of the invention
    brief description
    An object of the invention is a refractive multifocal intraocular lens useful for the replacement of the lens of the eye, hereinafter the lens of the invention, wherein: a) said lens, in its optical zone, comprises a surface anterior optic and a posterior optical surface aspherical and cut from a predetermined transparent material, said anterior and posterior optical surfaces being further separated by a predetermined central thickness, b) an elevation map of each of said anterior optical surfaces and posterior has a symmetry of revolution with respect to the optical axis of said lens, and a progressive and continuous evolution along the entire topography, c) an elevation along the radial coordinate of said anterior and posterior optical surfaces, taking as reference the plane tangent to the corneal apex, has a local minimum to z r0 corresponding to the center of the lens, said elevation further having one or more curvature inflection points before reaching at least one peripheral local maximum located within said optical zone and at a predetermined distance from the edge of said optical zone, giving rise to. a topography having a local minimum elevation in the center and at least one ring within said optical zone having a local elevation maximum, and d) a local optical power map within said optical zone , resulting from a combined optical refraction of said two aspherical optical surfaces and a model cornea external to and anterior to said lens, has a symmetry of revolution about the optical axis, and a central area of intermediate optical power surrounded in progressive transition by a ring of maximum optical power, behind which is a progressive alternation of rings of variable power, including at least one ring whose optical power is a local minimum with at least one ring whose optical power is a local maximum.
    Another object of the invention consists in a method for producing the lens of the invention, hereinafter the method of the invention, which comprises at least the following steps: a) mathematical definition of an aphaque model eye described at least by the geometry of the surface (s) defining the cornea, the axial position of the retina and the axial position of the plane in which the intraocular lens will be located following implantation, (b) mathematical definition of a pseudophakic model eye described by an aphaque model eye in which is implanted a model lens defined by means of a set of variable descriptive parameters within a set of boundary conditions which determine the geometry and characteristics of said lens, c) definition of a function of pluriconfiguration merit describing the optical quality of said pseudophakic model eye, said function integrating multiple configurations correspo ndant each at a distance from the object plane, associating a weighting with each of said configurations to provide as a result a single value representing the image quality of the system evaluated at different distances from the object plane, and d) optimizing said set descriptive parameters defining said lens for determining a set of descriptive parameters providing an optimal result of said pluriconfiguration merit function.
    detailed description
    The present invention describes for the first time a refractive multifocal intraocular lens of aspheric geometry on both surfaces such that the local optical power map of the lens, in combination with the cornea, has a central area of intermediate optical power surrounded by a ring of maximum optical power with a progressive transition zone between the 2, beyond which there is a progressive alternation of rings of variable power
    The lens provides a stable level of performance in terms of image quality, at the various focus points as well as in pupil changes, and simultaneously provides the patient with a highly contrasted vision, and an optimized optical quality for images. objects located in a wide range of distances, whether distant, near, or intermediate, with no significant falls in quality over the entire focal range, contrary to previous refractive and diffractive designs (Figure 3). The objective lens of the invention has an aspherical geometry on both surfaces, which makes it possible to obtain concentric zones of different powers, but with progressive transitions between these zones, and has been designed by optimizing the optical quality for different distances. simultaneously, its geometry and its power map being very different from refractive multifocal intraocular lenses belonging to the state of the art.
    Thus, this globally optimized configuration provides the best possible quality for all of the areas, in combination with the optical quality of the cornea of a pseudophakic model eye serving as a basis for the design of this lens and very different solutions simply multizone, with different curvatures on different areas of the lens. Thus, the variable power map of the produced lens provides similar multifocal benefits over a wide range of pupils of different sizes (Figure 4).
    It is furthermore described a method for producing this lens that implements a phase of optimizing its design parameters by means of a multiconfiguration merit function that simultaneously integrates multiple configurations each corresponding to a different distance from each other. in the object plane. The present invention therefore makes it possible to achieve a multifocal design with optical quality optimized at the various points of focus and therefore superior to other non-optimized solutions.
    The lens of the present invention overcomes many of the disadvantages of refractive and diffractive multifocal designs previously described. In particular, the lens of the present invention provides high optical quality in intermediate vision areas, unlike conventional multi-sectoral and diffractive refractive multifocal designs, which produce a fuzzy image in an extended area of intermediate vision. In addition, the lens of the present invention provides optical quality with little variation over a wide range of pupils, allowing performance independent of the size of the subject's natural pupil, changes in ambient brightness, or changes in diameter. of the pupil associated with the effort of accommodation. In this sense, the lens of the invention overcomes the limitations relating to previously described multifocal intraocular lenses. Optimization of optical quality, which is performed in association with a model cornea and simultaneously in a wide range of focal points, is one of the most relevant features of the invention. The present invention provides a method for designing a multifocal intraocular lens having optical quality optimized on the various focal points, preferably for objects between infinity and 0.40 m, characterized by aspherical surface geometry that provides a map of elevation of each of its surfaces which presents a symmetry of revolution with respect to the optical axis of the lens, and a smooth progression following the entirety of the topography.
    In addition to providing the lens, which is the object of the invention, with a stable and optimized optical quality over a wide range of focal points, the gentle alternation of local maxima and minima on the optical power map, accentuated on periphery, provides this lens a stable performance according to different pupillary diameters. These two characteristics mean that the performance of the lens surpasses those of the state of the art.
    Thus, an object of the invention consists of a refractive multifocal intraocular lens used for the replacement of the lens of the eye, hereinafter the lens of the invention, wherein: a) said lens, in its optical zone, comprises an anterior optical surface and a posterior optical surface and cut from a predetermined transparent material, said anterior and posterior optical surfaces being further separated by a predetermined central thickness, b) an elevation map of each of said optical surfaces. anterior and posterior has a symmetry of revolution with respect to the optical axis of said lens, and a progressive and continuous evolution along the entire topography, c) an elevation along the radial coordinate of said anterior and posterior optical surfaces, in taking as a reference the plane tangent to the corneal apex, presents a minimum a zero-local corresponding to the center of the lens, said elevation further having one or more curvature inflection points before reaching at least one peripheral local maximum located within said optical zone and at a predetermined distance from the edge of said optical zone, giving rise to a topography having a local minimum elevation in the center and at least one ring within said optical zone which has a local elevation maximum, and d) a local optical power map within said optical zone, resulting from a combined optical refraction of said two aspherical optical surfaces and a model cornea external to and anterior to said lens, has a symmetry of revolution about the optical axis, and a central zone of intermediate optical power surrounded in progressive transition by a ring of maximum optical power, behind which is located u progressive alternation of rings of variable power, in particular at least one ring whose optical power represents a local minimum with at least one ring whose optical power represents a local maximum.
    A particular object of the invention relates to a lens according to the invention, the optical zone has a diameter of between 4 and 7 mm.
    Another particular object of the invention relates to a lens according to the invention whose optical quality is stable and optimized on the various focal points in a range of pupillary diameters between 5 and 2.5 mm.
    Another particular object of the invention relates to a lens according to the invention which has a power for far vision of between +5 and +40 D.
    Another particular object of the invention relates to a lens according to the invention which has a central thickness of between 0.5 and 2 mm.
    Another particular object of the invention relates to the lens according to the invention which has a continuous transition zone from the optical zone to the haptic.
    Another particular object of the invention relates to the lens according to the invention which has: a) an optical power for far vision of a value of 22 D, b) a refractive index of the material of a value n = 1.5387, c) an anterior surface that is defined by the following parameters:
    d) a posterior surface that is defined by the following parameters:
    e) a central thickness of an ec value = 1.216464 mm, and f) an optimized and uniform optical quality for objects between infinity and 0.4 m distance.
    Another subject of the invention relates to a method of manufacturing a lens according to the invention, hereinafter the method according to the invention, which comprises at least the following steps: a) mathematical definition of a model eye aphaque described at least by the geometry of the surface (s) defining the cornea, the axial position of the retina and the axial position of the plane where the intraocular lens will be located following implantation, (b) mathematical definition of a pseudophakic model eye described by an aphakic model eye in which is implanted a model lens defined by means of a set of variable descriptive parameters within a set of boundary conditions which determine the geometry and characteristics of said lens, c) definition of a pluriconfiguration merit function describing the optical quality of said pseudophakic model eye, said function integrating multiple configurations each corresponding to a distance from the object plane, associating a weighting with each of said configurations to provide as a result a single value representing the image quality of the system evaluated at different distances from the object plane, and d) optimizing said set descriptive parameters defining said lens for determining a set of descriptive parameters providing an optimal result of said pluriconfiguration merit function.
    In step a), the geometry of the area (s) defining the cornea (see number 4 in Figure 1) is generally described by aspheric mathematical surfaces. It is not necessary that the geometrical description of the aphaque eye be complete, this one can be partial. The optical defects (whether these are those determined by a given topography of the cornea or by an ideal phase object) can be added to the description in simple geometric terms, called defects, which generally refer to optical aberrations, and especially those of lower order, such as myopia, hyperopia and astigmatism. These geometrical parameters, in a particular embodiment of the invention, correspond to representative descriptive parameters of a population, which may be as general as desired, or descriptive of a particular population group (age, ethnicity, error refractive or previously operated patients of the cornea, among others). In another particular embodiment of the invention, it may be parameters measured individually for each patient by biometric techniques.
    A particular object of the invention consists in the method of the invention in which the anterior (see No. 1 in FIG. 1) and posterior (FIG. 2 in FIG. 1) surfaces of the model lens mentioned in step b. ) are aspherical, have an elevation map symmetrical of revolution with respect to the optical axis of the lens and a smooth and continuous evolution along the whole topography. In a preferred embodiment of the method of the invention, but without limitation of the invention, the model lens mentioned in step b) comprises two aspherical surfaces, the former one (see number 1 in FIG. other posterior (see number 2 in Figure 1), defined by their radius of curvature, taper and asperity constants according to the following equation:
    where: z = sagittal of the surface at a certain radius "r" starting from the center, c = curvature at the center, k = conicity constant, and a, = each of the asherinity coefficients of order 4, 6, 8 , 10 and following.
    Another preferred embodiment of the invention consists of the method of the invention in which the distances with respect to the object plane of step c) at which the optical quality is optimized simultaneously are preferably between infinity and 0 , 2 m. Integration of the multiconfiguration merit function of the various configurations can be done by multiplying the result of each of the configurations by some weightings which determine the relative importance of the vision at different distances and ensure the convergence of the posterior optimization. The result of the pluriconfiguration merit function provides an estimate of the optical quality, based on the parameters of the model lens.
    Another preferred embodiment of the invention consists in the method of the invention in which the result of the pluriconfiguration merit function is obtained after the ray tracing through the pseudophakic eye (which includes the model lens), for each configurations (corresponding to each object distance). The numerical evaluation of the optical quality in each configuration can be carried out in various ways, well known in the field of optical design, such as, for example, in terms of the average square root of the wavefront in the plane of the pupil or of the impact diagram in the image plane.
    Another preferred embodiment of the invention consists in the method of the invention in which the optimization step d) is carried out according to an iterative process.
    The method of the invention is similarly performed for eyes of different axial length and therefore capable of receiving intraocular lenses of different power for distance vision.
    Another particular object of the invention consists in the method of the invention in which the lens is a multifocal refractive intraocular lens of determined power for distance vision and in which, in the definition of the aphaque eye model, the length Axial is used in order that the focused retinal image is produced by a spherical monofocal lens of the same refractive power. More concretely, in a preferred embodiment, the nominal power for far vision of the refractive multifocal lens is determined by that whose value is optimized for a focusing range for an eye with an axial length such as a monofocal surface lens. spherical, of the same material and thickness, with the same power rating, will generate the best image, on the retina, of an object located 5 meters from the retina.
    Finally, another subject of the invention consists of a refractive multifocal intraocular lens made according to the method of the invention.
    Description of figures
    Figure 1.- Geometry of the cornea of the eye implemented in the design and lens of the invention. Anterior optical surface 1 of the lens, posterior optical surface 2 of the lens, plane 3 tangent to the apex of the cornea 4, local minimum to zero 5 which corresponds to the center of the lens, and one or more points of inflection of curvature 6, maximum local peripheral 7 and limit of the optical zone 8.
    Figure 2.- Power map obtained from the combination of the refraction of light rays by the two aspherical optical surfaces of the lens of the invention and a model cornea external to and anterior to the lens 4. Central optical power zone intermediate 9, maximum optical power ring 10, a ring whose optical power is a local minimum 11 with at least one ring whose optical power is a local maximum 12.
    Figure 3.- Modulation transfer function of the eye implemented in the design with the lens of the invention for a spatial frequency of 50 c / mm depending on the object distance, for various pupil diameters. The various lines and symbols represent the behavior for various pupil diameters (D), between 5 and 3 mm.
    Figure 4.- Modulation transfer function of the eye implemented in the design with the lens of the invention for a spatial frequency of 50 cycles / mm depending on the diameter of the pupil, for different object distances. The different lines and symbols represent the behavior for different object distances, between 0.4 and 5 m.
    Embodiment of the Invention As an illustration of the present invention, an exemplary embodiment of a multifocal refractive lens is described having a pupillary diameter of 5 mm (effective diameter of the optical zone of the lens of 4.3 mm) and a refractive index of 1.5387 (hydrophobic material).
    To obtain the drawing of the presented lens, an eye model is used presenting the following geometrical parameters, summarized in Table 1:
    Table 1
    Table 2 presents the values obtained for the geometrical parameters of the multifocal refractive lens in the preferred embodiment of the invention (two aspherical surfaces, with 7 parameters each), where ec is the central thickness of the lens.
    Table 2
    The profile of the anterior and posterior surfaces of the designed refractive intraocular lens is that graphically illustrated in Figure 1. As can be seen from Figure 1, both on the anterior optical surface 1 of the lens and on the optical surface posterior 2, the elevation along its radial coordinate, taking as a reference plane 3 tangent to the apex of the cornea 4, has a local minimum at zero 5, which corresponds to the center of the lens, and one or more bending inflection points 6 before reaching at least a local peripheral maximum 7 located in the interior of the optical zone and at a distance from the edge of the optical zone 8, giving rise to a topography containing a local minimum of elevation in the center and at least one ring in the optical zone consisting of a local elevation maximum.
    FIG. 2 illustrates the power map obtained from the association of the aphakic model eye, the refraction of the light rays by the two aspherical optical surfaces of the lens, the anterior surface 1 and the posterior surface 2, and a model cornea external and anterior to the lens 4. This power card further characterizes the lens object of the present invention, and has the alternation of annular zones of different soft-transition refractive powers. Within the optical zone, the local optical power has a symmetry of revolution about the optical axis, and a central area of intermediate optical power 9 smoothly transitioned by a ring of maximum optical power 10, behind which finds a gentle alternation of rings of variable power and in particular at least one ring whose optical power is a local minimum 11 with at least one ring whose optical power is a local maximum 12.
    In this embodiment of the invention, the function meritpluriconfiguration has been created by adding the average square root of the wavefront of each configuration corresponding to the different observation distances, which are 5; 4; 3; 2; 1; 0.8; 0.6 and 0.4 meters, with standardized weights 0.311; 0.044; 0.044; 0.044; 1.78; 0.088; 0.088; 0.444 respectively. As boundary conditions, a center thickness of 0.6 to 1.2 mm was considered; an edge thickness of between 0.25 and 0.4 mm haptic and a sagittal maximum of 1.5 mm.
    In order to evaluate the benefits of the new refractive multifocal intraocular lens, it was evaluated by computer on the generic eye implemented in the design using conventional ray tracing algorithms (Zemax). The benefits of the new lens are described by means of the modulation transfer function (MTF) at 50 c / mm of the pseudophakic model eye in which said lens is implanted on the various points of focus. Figure 3 illustrates the evolution of the modulation for different object distances, as a function of the pupil diameter. The MTF retains values greater than 0.45 over the entire focus range (pupils between 3 and 5 mm in diameter), reaching 0.65 for near and far vision and 0.58 for intermediate distances (for pupil 4.5 mm in diameter). These values are similar to or greater than those obtained at the far and near vision focal points of a diffractive multifocal lens of the state of the art available on the market, but the refractive multifocal intraocular lens object of the invention offers in the intermediate zone much higher values, which therefore offer good optical quality for intermediate vision.
    The optical quality of this lens as a function of the size of the pupil remains practically constant, between 3 and 5 mm of pupil diameter, as shown in FIG. 4.
    The lens offers multifocal benefits of similar characteristics to those already described, in combination with different model eyes based on biometric data different from those of the eye implemented in the design, corresponding to real eyes.
    权利要求:
    Claims (18)
    [1]
    1. Refractive multifocal intraocular lens used for the replacement of the lens of the eye characterized in that: a) said lens, in its optical zone, comprises an anterior optical surface and a posterior optical surface aspherical and cut from a predetermined transparent material, said anterior and posterior optical surfaces being further separated by a predetermined central thickness, b) an elevation map of each of said anterior and posterior optical surfaces has a symmetry of revolution with respect to the optical axis of said lens, and a gradual and continuous evolution along the entire topography, c) an elevation along the radial coordinate of said anterior and posterior optical surfaces, taking as a reference the plane tangent to the corneal apex, presents a local minimum to zero corresponding to the center of the lens, said elevation p further resenting one or more curvature inflection points before reaching at least one peripheral local maximum located within said optical zone and at a predetermined distance from the edge of said optical zone, giving rise to a topography presenting a local elevation minimum at the center and at least one ring within said optical zone which has a local elevation maximum, and d) a local optical power map within said optical zone, resulting from a combined optical refraction of said two aspherical optical surfaces and a model cornea external to and anterior to said lens, has a symmetry of revolution about the optical axis, and a central area of intermediate optical power surrounded in progressive transition by a ring of maximum optical power, behind which there is a progressive alternation of rings of variable power, in particular at the oins a ring whose optical power represents a local minimum with at least one ring whose optical power represents a local maximum.
    [2]
    2. - Refractive multifocal refrocentric intraocular lens according to claim 1, characterized in that said optical zone has a diameter of between 4 and 7 mm.
    [3]
    3. - Refractive multifocal refractive intraocular lens according to claim 1, characterized in that it has an optical quality on the various focal points stable and optimized in a range of pupil diameters between 5 and 2.5 mm.
    [4]
    4. - Refractive multifocal refrocentric intraocular lens according to claim 1, characterized in that it has a power for distance vision of between +5 and +40 D.
    [5]
    5. - Refractive multifocal refrocentric intraocular lens according to claim 1, characterized in that it has a central thickness of between 0.5 and 2 mm.
    [6]
    6. - Refractive multifocal refrocentric intraocular lens according to claim 1, characterized in that it has a continuous transition zone from the optical zone to the haptic.
    [7]
    7. - refractive multifocal refractive intraocular lens according to claim 1, characterized in that the lens has: a) an optical power for distance vision having a value of 22 D, b) a refractive index of the material having a value n = 1.5387, c) an anterior surface defined by the following parameters:

    d) a posterior surface defined by the following parameters: R = -0.262811 mm; K = -3.690784e + 39, a2 = 0.1288675, a3 = -0.046277, a4 = 4.546855e'3, a5 = -1.458619e · 4, e) a central thickness having a value ec = 1 , 216464 mm, and f) Optimized and uniform optical quality for objects between infinity and 0.4 m distance.
    [8]
    8. - A method of manufacturing a multifocal refractive intraocular lens according to claim 1, characterized in that it comprises at least the following steps: a) mathematical definition of an aphaque model eye described at least by the geometry of the or surfaces defining the cornea, the axial position of the retina and the axial position of the plane where the intraocular lens will be located following implantation, b) mathematical definition of a pseudophakic model eye described by an aphaque model eye in which is implanted a model lens defined by means of a set of variable descriptive parameters within a set of boundary conditions which determine the geometry and characteristics of said lens, c) definition of a pluriconfiguration merit function describing the optical quality of said pseudophakic model eye, said function integrating multiple configurations corresponding each e at a distance from the object plane, associating a weighting with each of said configurations to provide as a result a single value representing the image quality of the system evaluated at different distances from the object plane, and d) optimizing said set of descriptive parameters defining said lens to determine a set of descriptive parameters providing an optimal result of said pluriconfiguration merit function.
    [9]
    9. - A method of manufacturing a multifocal refractive intraocular lens according to claim 8, characterized in that said mathematical definition of an aphaque model eye mentioned in a) implements descriptive parameters representative of a particular population.
    [10]
    10. - A method of manufacturing a refractive multifocal intraocular lens according to claim 8, characterized in that said mathematical definition of an aphaque model eye mentioned in a) implements biometric parameters specific to a given patient.
    [11]
    11. - A method of manufacturing a refractive multifocal intraocular lens according to claim 8, characterized in that the anterior and posterior surfaces of the model lens mentioned in step b) are aspherical, have a symmetrical elevation map. revolution with respect to the optical axis of said lens and a progressive evolution along the entire topography.
    [12]
    12. - A method of manufacturing a multifocal refractive intraocular lens according to claim 11, characterized in that said aspherical surfaces, one anterior and the other posterior, are defined by their radius of curvature, their conicity and constants d asphericity according to the following equation:

    where: z = sagittal of the surface at a certain radius "r" starting from the center, c = curvature at the center, k = conicity constant, and a, = each of the asherinity coefficients of order 4, 6, 8 , 10 and following.
    [13]
    13. - A method of manufacturing a multifocal refractive intraocular lens according to claim 8, characterized in that said distances relative to the object plane of step c) which is optimized optical quality simultaneously are distances between infinity and 0.4 m, preferably between infinity and 0.2 m.
    [14]
    14. - A method of manufacturing a multifocal refractive intraocular lens according to claim 8, characterized in that said result of the merit function pluriconfiguration mentioned in step c) is obtained after the ray tracing through a pseudophakic eye comprising the model lens, for each of the configurations corresponding to each distance from the object.
    [15]
    15. - A method of manufacturing a refractive multifocal intraocular lens according to claim 8, characterized in that the optimization step d) is carried out according to an iterative process.
    [16]
    16. - A method of manufacturing a multifocal refractive intraocular lens according to claim 8, characterized in that it is the manufacture of a determined power lens for distance vision and in that, at the step a) of mathematical definition of an aphaque model eye, the axial length of the eye is that which provides, with a spherical monofocal lens of the same refractive power, a focused retinal image.
    [17]
    17. - A method of manufacturing a multifocal refractive intraocular lens according to claim 16, characterized in that the nominal power for the far vision of the refractive multifocal lens is determined by that whose value is optimized over a range of focus for an eye with an axial length such as a monofocal lens of spherical surfaces, of the same material and thickness, with the same nominal power, and which will generate the best retinal image, of an object located at 5 meters.
    [18]
    18. - Multifocal refrocentric intraocular lens characterized in that it is carried out according to a method according to one of claims 8 to 17.
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    FR3098707A1|2021-01-22|Widened near vision diffractive eye implant
    US20210369445A1|2021-12-02|Double-sided aspheric diffractive multifocal lens, manufacture, and uses thereof
    NL2008054C2|2013-07-03|A trifocal intraocular lens.
    同族专利:
    公开号 | 公开日
    KR101937709B1|2019-01-14|
    CA2896249A1|2014-07-03|
    BR112015015471B1|2021-05-18|
    CA2896249C|2020-01-07|
    US20150342727A1|2015-12-03|
    WO2014102352A1|2014-07-03|
    ES2472121A1|2014-06-27|
    BR112015015471A2|2017-07-11|
    AU2013369217B2|2018-09-13|
    EP2941222A1|2015-11-11|
    AU2013369217A1|2015-07-23|
    US10226327B2|2019-03-12|
    JP6259834B2|2018-01-10|
    ES2472121B1|2015-04-13|
    JP2016501650A|2016-01-21|
    KR20150130970A|2015-11-24|
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    法律状态:
    优先权:
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    ES01232043|2012-12-27|
    ES201232043A|ES2472121B1|2012-12-27|2012-12-27|Refractive multifocal intraocular lens with optimized optical quality in a focus range and procedure to obtain it|
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